Peptide Stapling Using Sonogashira Coupling.

• Tác giả: Susanta Kumar Behera, Devki Nandan, Ramesh Ramapanicker
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Chembiochem : a European journal of chemical biology , 2025
• Bộ sưu tập: NCBI
• ID: 712792

Tóm tắt

An efficient method for the stapling of peptides by linking residues at the i and i+4 or i and i+7 positions through Sonagashira coupling is reported. The alkyne and aryl iodide functionality required are introduced by modifying tyrosine residues to 4-iodophenylalanine (PhI) and 4-propargyloxyphenylalanine (TyP) residues. Comparing the conformations of a stapled peptide with the corresponding linear peptide using CD spectroscopy reveals a more helical structure for the stapled peptide.