Nickel-Catalyzed Dynamic Kinetic Asymmetric Reductive Arylation of Aldehydes with Heterobiaryl Triflates.

• Tác giả: Xinran Ding, Chuan Wang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Organic letters , 2025
• Bộ sưu tập: NCBI
• ID: 713025

Tóm tắt

In this context, we report a nickel-catalyzed dynamic kinetic asymmetric reductive arylation of aldehydes with racemic heterobiaryl triflates, offering a series of axially chiral heterobiaryls bearing a centrally chiral secondary alcohol moiety in a highly diastereo- and enantioselective manner. The simultaneous control of both axial and central stereogenic elements of the products lies in the stereoselective nucleophilic addition of the configurationally labile hetereobiaryl nickel complex to the formyl group of aldehydes.