Although the concepts of mental well-being, difficulties in emotion regulation, resilience, and psychological distress have been investigated in cross-sectional studies, their absence from a longitudinal study demonstrates a gap in the literature. Following the earthquake disaster in Türkiye, addressing these concepts together in a longitudinal study may offer important implications for the field of mental health. The longitudinal mediation of resilience and psychological distress in the relationship between difficulties in emotion regulation and mental well-being was investigated in a Turkish adult sample. The study sample consisted of 219 participants aged between 18 and 45 (51.1% male, M