Palmoplantar Pustulosis as an Immune-Mediated Inflammatory Disease with a Possible Relevance of Th17 Cell Plasticity: A Narrative Review.

• Tác giả: Hideki Fujita, Koremasa Hayama, Masamoto Murakami, Yukari Okubo, Tadashi Terui
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : Dermatology and therapy , 2025
• Bộ sưu tập: NCBI
• ID: 713116

Tóm tắt

Palmoplantar pustulosis (PPP) is an immune-mediated inflammatory disease (IMID) of the skin that causes the formation of sterile pustules on the palms and soles. The clinical course of PPP is variable, with some patients having persistent skin lesions and others having lesions that wax and wane repeatedly. PPP has been treated with drugs such as those used for plaque psoriasis. The efficacy of biologics targeting the interleukin (IL)-23-helper T (Th)17 axis is not as conspicuous in PPP as in plaque psoriasis. Traditionally, CD4