The predictive value of postoperative soluble urokinase plasminogen activator receptor concentration for postoperative complications following valvular surgery.

• Tác giả: Alain Dardashti, Clara Erixon, Emilia Johannesson, Adam Linder, Johan Nilsson, Sigurdur Ragnarsson, Niklas Sterner, Karl Teurneau-Hermansson, Louise Thelaus, Igor Zindovic
• Ngôn ngữ: eng
• Ký hiệu phân loại: 929.10284 Genealogy
• Thông tin xuất bản: England : Scandinavian journal of clinical and laboratory investigation , 2025
• Bộ sưu tập: NCBI
• ID: 713161

Tóm tắt

Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker that has been shown to predict poorer outcomes in cardiovascular disease and after cardiac surgery. The relationship between suPAR concentrations and postoperative complications after valvular surgery, however, remains unclear. This study aims to evaluate the predictive value of suPAR concentrations for infection, acute kidney injury (AKI) and prolonged mechanical ventilation after valvular surgery. This prospective, observational, single-centre study included 414 patients who underwent valvular cardiac surgery at Skåne University Hospital between 1 February 2020 and 22 September 2021. Early postoperative suPAR levels were measured, and multivariable logistic regression was used to identify significant risk factors for postoperative infection, AKI and prolonged mechanical ventilation. Left ventricular ejection fraction (LVEF) 30-50% (OR 3.57 [1.29-9.86],