Psoriasis is a chronic autoimmune skin disease that has been associated with many polymorphic genes based on genome-wide association studies (GWAS). To perform gene ontology and biological pathway analysis of genes associated with psoriasis and also to investigate the degree of commonality of psoriasis-associated loci with susceptibility loci of some other autoimmune diseases, a total of 319 psoriasis-associated polymorphic protein-coding genes were included in the analysis. The web-based Enrichr was used for performing present analysis. Cytokine-cytokine receptor interaction and JAK-STAT signaling were predicted by KEGG analysis. The top biological process and molecular function were positive regulation of cytokine production and cytokine receptor activity, respectively. The present findings revealed that the psoriasis-associated genes were significantly involved in the immune system and its functions, consistent with the autoimmune nature of the disease. The present study revealed that there were 10 genes shared between psoriasis and other 5 autoimmune diseases, interestingly, these genes were significantly enriched in the JAK-STAT pathway (adjusted p-value = 3.75e-5). There were several multifactorial diseases and complex traits that had a statistically significant commonality between their predisposing genes and psoriasis predisposing genes. The current findings suggest that the JAK-STAT pathway is likely involved in the pathogenesis of psoriasis, such as many other autoimmune diseases. Therefore, it is suggested that inhibitors that block the gene transcription of pro-inflammatory cytokines by blocking intracellular signaling pathways mediated by JAK-STAT may be a good model for the treatment of autoimmune diseases, including psoriasis.