The second edition of the Buenos Aires Breast Cancer Symposium (BA-BCS), the first held in person, took place from September 3rd to 6th in Buenos Aires, Argentina. This report provides an overview of the talks delivered as individual lectures or as part of the mini-symposia illustrating the diversity and complexity of the topics discussed throughout the meeting. The event brought together leading scientists and clinical experts dedicated to advancing breast cancer research and improving therapeutic strategies and patient care. The contributions from both speakers and attendees fostered an extraordinary atmosphere at the gathering in Buenos Aires. We hope these interactions will lead to more translational approaches and promote future collaborations.