Reports on the use of plasma skin regeneration for the treatment of acne vulgaris are limited. We aimed to report on the effectiveness of nitrogen PSR in the treatment of acne vulgaris. Participants with acne vulgaris were enrolled and underwent three consecutive PSR sessions at 4-week intervals. Facial surface analysis was performed as an evaluation of treatment efficacy through objective computerized evaluation using the Canfield VISIA imaging system. Post-treatment subjective evaluations were performed and analyzed using the Clinical Global Impression Improvement Scale (CGI-I) and the Patient Global Impression Improvement Scale (PGI-I). Pain levels and other complications were recorded at each follow-up visit. At 2 months after the final treatment, the patients' subjective evaluation of the treatment was obtained. Twenty patients were included in the analysis. There was a significant improvement in the porphyrin VISIA System score and in the erythematous area. Additionally, the fine lines, pores, and skin texture showed significant improvements after three sessions, and both the mean CGI-I and PGI-I scores improved significantly. Two patients experienced temporary acne worsening
however, no other side effects were observed. All patients were satisfied with the treatment and did not report any significant adverse effects on their lifestyle. Nitrogen PSR is an effective and safe treatment for inflammatory acne, with minimal recovery time and no significant complications.