Cancer immunotherapy represents a promising strategy, however, its efficacy is often hindered by high tumor interstitial fluid pressure (TIFP) due to fluid retention, and strong solid stress (SS) caused by the excessive proliferation of cancer-associated fibroblasts (CAFs). These factors limit the infiltration of immune cells into the deeper layers of tumors, thereby reducing the efficacy of immunotherapy. In this study, we designed an innovative AgNbO