Patients with single ventricle heart disease (SVHD) require multiple palliative surgeries. Due to high mortality rates observed during the four to sixth-month interstage period between the first and second surgery, at-home monitoring practices are important. However, modern-day interstage monitoring does not offer comprehensive quantitative tracking of health conditions since it relies on logging the infant's weight, feeding patterns, and oxygen saturation once a day in a journal. Here, we introduce a soft wearable electronic device for the home monitoring of SVHD patients. The ultrathin, imperceptible, wireless system is designed for safe integration with infants' delicate skin. The system features a chest-mounted biopatch and forehead-mounted pulse oximeter, streaming real-time data to a cloud-based platform. This smart device has built-in alert functions to help caregivers recognize when the patients should be returned to the hospital for in-person observation, easing decision-making from non-clinically trained personnel. In addition, the patient-tailored database also improves the communication between the home and hospital, reducing the load on caretakers during this stressful period.