Excessive anxiety regarding the potential for accidental and fatal cross-contamination is very common among patients and families with food allergy and contributes significantly to burden, reduced quality of life, and poorer management. In their landmark paper published nearly a decade ago, Dinakar and colleagues recommended that food allergists incorporate proximity food challenges such as smelling or touching an allergen into regular clinical practice to improve patient knowledge regarding safety and relative risk and reduce anxiety. Such proximity challenges are akin to the exposure tasks routinely employed to treat anxiety in cognitive-behavioral therapy (CBT), the first-line psychosocial intervention for anxiety disorders. Exposure is a highly evidence-based therapy technique where patients - guided and encouraged by their providers - directly and strategically confront a feared object, situation, or activity. Anxiety eventually diminishes and erroneous beliefs are corrected when exposures happen repeatedly in the absence of the feared negative outcome. Following a summary of the history and evidence-base for exposure in both the psychiatric and food allergy literature, we review several considerations related to conducting in-office proximity challenges. Topics include in-office assessment of food allergy anxiety and medically unnecessary avoidance
choosing appropriate, individualized proximity challenges based on patient presentation
and practical considerations in carrying out in-office proximity challenges to maximize benefits to anxious patients.