Due to their extremely low background signal and high sensitivity, the chemiluminescence (CL) probes have received a great attention in various chemical and biological applications. However, the lack of selectivity is still a challenging task. As an innovative topic of research, in this work we developed a domino-like turn-on CL reaction through proximal-imidazole species for the first time. The oxidation reaction of N-(2H-[1,2,4]thiadiazolo[2,3-a]pyridine-2-ylidene)benzamide (1) by hydrogen peroxide found to promoted by a domino-like reaction between proximal imidazole species and the Co