Effect of hexyloxy position on antagonistic properties of KH-5 (1-{2-[4-(hexyloxy)benzoyloxy]ethyl}-1-methyl-1,2,3,6-tetrahydropyridin-1-ium iodide) at muscarinic acetylcholine receptors.

• Tác giả: Jana Bláhová, Nikolai Chetverikov, Eva Dolejší, Jan Jakubík, Alena Janoušková-Randáková, Jan Korábečný, Eva Mezeiová, Dominik Nelic, Martin Novák, Lukáš Prchal
• Ngôn ngữ: eng
• Thông tin xuất bản: France : Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie , 2025
• Bộ sưu tập: NCBI
• ID: 713792

Tóm tắt

Antagonists with a long residence time at the receptors are desired for the possibility of reducing daily doses and side effects. KH-5 (1-{2-[4-(hexyloxy)benzoyloxy]ethyl}-1-methyl-1,2,3,6-tetrahydropyridin-1-ium iodide) is the long-acting M