Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are two methods used to detect hemodynamically significant lesions and guide revascularization. Discrepancies between FFR and iFR values can complicate revascularization decisions. We present a series of six cases with discrepant FFR and iFR results. Among them, five were men, five had lesions in the right coronary artery, and one had left anterior descending disease, with an average age of 61.7±11.1 years. All patients were iFR negative (mean iFR 0.94±0.02) and FFR positive (mean FFR 0.75±0.04). Consequently, all patients underwent revascularization.