Design, synthesis, and biological evaluation of novel aminopyrimidine derivatives as EGFR inhibitors.

• Tác giả: Shengkai Cui, Weizheng Fan, Yule Gui, Xinyi Long, Chunlei Tang, Huabing Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.8552 Diseases of nervous system and mental disorders
• Thông tin xuất bản: England : Bioorganic & medicinal chemistry letters , 2025
• Bộ sưu tập: NCBI
• ID: 713899
• Chủ đề: 1. Design; 2. Synthesis; 3. And

Tóm tắt

The treatment of non-small cell lung cancer (NSCLC) is significantly challenged by the development of acquired resistance to third-generation epidermal growth factor receptor (EGFR) inhibitors, such as Osimertinib, which limits their therapeutic efficacy. Using the EGFR