OBJECTIVE AND METHODS: We retrospectively assessed protection against HBV (defined by HBs Ab >
10 UI/L), HAV (defined by positive IgG), and HPV (defined by at least one shot) in 1161 patients aged 18---30 years old who consulted at an HIV and STI screening center (CeGIDD) between May 2023 and May 2024. Results are presented by gender, sexual orientation and PrEP use. RESULTS: All in all, 59% (621/1051) of the population was HBV-immune. Among MSM, bisexual men and transgender people, 17% (18/105) were HAV-immune, a proportion rising to 40% (42/105) at the end of the study period. Among PrEP patients, 18% (13/78) were HAV-immune and 64% (50/78) were HBV-immune. HPV vaccination was given to 12% (68/569) of women, 13% (72/583) of men, 37% (54/147) of MSM, bisexual men and transgender patients, and to 41% (32/78) of PrEP users. CONCLUSION: All health workers should be fully aware of the relevant recommendations and actively involved in enhancing patient protection.