ctDNA variations according to treatment intensity in first-line metastatic colorectal cancer.

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Tác giả: Ludivine Beaussire-Trouvay, Anne-Laure Bignon, Valérie Blondin, Karine Bouhier-Leporrier, Tifenn Clabaut, Frédéric Di Fiore, Marie Dutherage, Caroline Elie, Marie-Pierre Galais, Alice Gangloff, André Gilibert, Adrien Grancher, Emilie Lévêque, Pierre Michel, Aurélie Parzy, Jean-Christophe Sabourin, Lilian Schwarz, David Sefrioui, Nasrin Vasseur, Virginie Vernon

Ngôn ngữ: eng

Ký hiệu phân loại: 785.13 *Trios

Thông tin xuất bản: England : British journal of cancer , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 714320

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BACKGROUND: Circulating tumor DNA variations (∆ctDNA) were reported to be associated with treatment efficacy in metastatic colorectal cancer (mCRC). The present study evaluated ∆ctDNA according to first-line treatment intensity. METHODS: Patients from two prospective ctDNA collections were divided into Group ≤ 2 drugs and Group ≥ 3 drugs. ∆ctDNA were analysed from baseline to cycle 3 or 4 (C RESULTS: Pretreatment ctDNA was detected in 129/152 (84.9%) of patients. A ∆ctDNA ≥ 80% DISCUSSION: Early ∆ctDNA are associated to treatment intensity in first line mCRC with a significant impact on prognosis.

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