BACKGROUND: Gastrointestinal stromal tumors (GISTs) are relatively rare, accounting for approximately 0.1-3% of all gastrointestinal tumors. Their incidence is higher in individuals aged 50 to 70 years, with an equal gender distribution. Due to their diverse clinical presentations, including upper gastrointestinal (GI) bleeding and gastric discomfort, along with an indolent growth pattern, GISTs can remain undetected for extended periods. This delay in diagnosis can lead to complications. Diagnosis involves upper GI endoscopy, computed tomography (CT) scan, biopsy with histologic grading, and immunohistochemical testing for CD-117 and CD34. The higher incidence of GISTs in patients with obesity underscores the need for preoperative upper GI endoscopic screening. CASE PRESENTATION: A 31-year-old female with a history of sleeve gastrectomy (SG) for obesity (BMI 38 kg/m CONCLUSION: Early detection and sleeve-preserving resection of GISTs in post-sleeve gastrectomy patients ensure effective tumor management while maintaining gastric integrity. This case highlights the importance of preoperative evaluation and long-term follow-up in these patients.