Superior preclinical efficacy of co-treatment with BRG1/BRM and FLT3 inhibitor against AML cells with FLT3 mutations.

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Tác giả: Kapil N Bhalla, Christine E Birdwell, Mike Collins, Branko Cuglievan, Kaberi Das, Naval Daver, John A Davis, Courtney D DiNardo, Warren Fiskus, Lauren B Flores, Danielle Hammond, Murphy Hentemann, Hanxi Hou, Antrix Jain, Tapan M Kadia, Sanam Loghavi, Anna Malovannaya, Christopher P Mill, Jessica Piel, Patrick K Reville, Koji Sasaki, Xiaoping Su, Koichi Takahashi

Ngôn ngữ: eng

Ký hiệu phân loại: 532 Fluid mechanics Liquid mechanics

Thông tin xuất bản: United States : Blood cancer journal , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 714344

Although treatment with standard frontline therapies, including a FLT3 inhibitor (FLT3i) reduces AML burden and achieves clinical remissions, most patients with AML with FLT3 mutation relapse due to therapy-resistant stem/progenitor cells. The core ATPases, BRG1 (SMARCA4) and BRM (SMARCA2) of the canonical (c) BAF (BRG1/BRM-associated factor) complex is a dependency in AML cells, including those harboring FLT3 mutations. We have previously reported that treatment with FHD-286, a BRG1/BRM ATPases inhibitor, induces differentiation and loss of viability of AML stem/progenitor cells. Findings of present studies demonstrate that treatment with FHD-286 induces lethality in AML cells, regardless of sensitivity or resistance to FLT3i. This efficacy is associated with the induction of gene-expression perturbations responsible for growth inhibition, differentiation, as well as a reduced AML-initiating potential of the AML cells. Additionally, co-treatment with FHD-286 and FLT3i exerts superior pre-clinical efficacy against AML cells and patient-derived (PD) xenograft (PDX) models of AML with FLT3 mutations.
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