Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function.

• Tác giả: Gabriel Ascui, Vivek Chandra, Ting-Fang Chou, Martina Dicker, Mitchell Kronenberg, Yingcong Li, Thomas Riffelmacher, Benjamin Schmiedel, Pandurangan Vijayanand
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.831 *Alzheimer disease
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 714431

Tóm tắt

Genome wide association studies (GWAS) identify many risks for Crohn's disease (CD), including a site near the metabolism gene laccase domain containing 1 (LACC1). We previously found this site near LACC1 was associated with decreased LACC1 expression in T lymphocytes, yet the mechanism affecting gene expression and its links to T cell function and inflammatory disease were unknown. Here we identify variants in the promoter region that influence transcription of LACC1. Direct association of disease-risk variants with lower LACC1 pre-mRNA in human CD4