Axonal RNA localization is essential for long-term memory.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Florence Besse, Lauren Blot, Chantal Cazevieille, Ugur Dag, Fabienne De Graeve, Bruna R de Queiroz, Marine Dehecq, Marion Dunoyer de Segonzac, Martina Hallegger, Arnaud Hubstenberger, Krystyna Keleman, Hiba Laghrissi, Seetha Rajeev, Mirana Ramialison, Jernej Ule

Ngôn ngữ: eng

Ký hiệu phân loại: 658.32259 Personnel management (Human resource management)

Thông tin xuất bản: England : Nature communications , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 714432

Localization of mRNAs to neuronal terminals, coupled to local translation, has emerged as a prevalent mechanism controlling the synaptic proteome. However, the physiological regulation and function of this process in the context of mature in vivo memory circuits has remained unclear. Here, we combined synaptosome RNA profiling with whole brain high-resolution imaging to uncover mRNAs with different localization patterns in the axons of Drosophila Mushroom Body memory neurons, some exhibiting regionalized, input-dependent, recruitment along axons. By integrating transcriptome-wide binding approaches and functional assays, we show that the conserved Imp RNA binding protein controls the transport of mRNAs to Mushroom Body axons and characterize a mutant in which this transport is selectively impaired. Using this unique mutant, we demonstrate that axonal mRNA localization is required for long-term, but not short-term, behavioral memory. This work uncovers circuit-dependent mRNA targeting in vivo and demonstrates the importance of local RNA regulation in memory consolidation.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH