General practice-based care for Australian children is facing low levels of clinical guideline adherence particularly in three key areas: asthma, type 1 diabetes and antibiotic use. We offer an implementation science-informed position paper, providing a broad overview of how we aim to address this issue. This is the co-designed National Paediatric Applied Research Translation Initiative (N-PARTI), a bespoke, three-phased research solution by deploying mixed methods, simulation and scale-up of evidence into practice.