Management of the patent ductus arteriosus among infants born at 23 to 32 weeks' gestation between 2011 to 2022: a report from in the Children's Hospitals Neonatal Consortium.

• Tác giả: Molly K Ball, Sharada H Gowda, Theresa R Grover, Sharifa Habib, Shannon Hamrick, Sarah Keene, Philip T Levy, Karna Murthy, Michael Padula, Ranjit Philip, Rakesh Rao, Shawn Sen, Mark F Weems, Isabella Zaniletti
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of perinatology : official journal of the California Perinatal Association , 2025
• Bộ sưu tập: NCBI
• ID: 714600

Tóm tắt

 OBJECTIVE: This study reports on patent ductus arteriosus (PDA) therapy trends across the Children's Hospital Neonatal Consortium. STUDY DESIGN: We performed a 12-year (2011-2022) retrospective study of premature infants (<
  33 weeks) with a PDA. We utilized descriptive statistics to compare demographic, inpatient, and discharge characteristics in 3-year epochs. RESULT: From 54,813 infants, 19,843 (36%) had a diagnosis of PDA. Use of pharmacotherapy increased 44% (relative) over time, mostly with increased acetaminophen use. There was a 12.7-fold increase in exposure to multiple PDA medications over the study period. While the rate of definitive closure did not change, use of transcatheter PDA closure increased from 0 to 20.3% and surgical ligation decreased from 25.1% to 3.6%. CONCLUSION: There has been an increase in the use of multiple pharmacotherapies for PDA, especially among infants born <
 27 weeks' gestation. Transcatheter PDA closure has overtaken surgical ligation as the primary method of definitive PDA closure.