Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ-PIAS1-5/miR-219a-2-3p/TEAD1 Axis.

• Tác giả: Zhigang Bai, YueE Chai, Ning Ding, Yideng Jiang, Yun Jiao, Nan Li, Fei Ma, Shengchao Ma, Jiangyong Shen, Kai Wu, Lin Xie, Jiantuan Xiong, Anning Yang, Huiping Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Advanced science (Weinheim, Baden-Wurttemberg, Germany) , 2025
• Bộ sưu tập: NCBI
• ID: 714729

Tóm tắt

Previous studies have established a possible link between hyperhomocysteinemia (HHcy) and dyslipidemia. Circular RNAs (circRNAs) play important regulatory roles in the development of atherosclerosis. However, the biological functions and potential molecular mechanisms of circRNAs in HHcy-induced lipid accumulation leading to atherosclerosis are still unclear. In this study, it is determined that homocysteine (Hcy) downregulates the expression of circ-PIAS1-5 by global circRNA expression profiling and that circ-PIAS1-5 inhibits Hcy-mediated lipid accumulation in foam cells and the pathogenesis of atherosclerosis by acting as a sponge for miR-219a-2-3p. Circ-PIAS1-5 is identified as a potential diagnostic biomarker of HHcy-associated atherosclerosis in male "apolipoprotein E knockout (ApoE