Coronary atherosclerosis, a progressive disease, has long been the focus of clinical investigations aimed at understanding its natural evolution and response to medical therapies. While traditional imaging modalities, such as intravascular ultrasound (IVUS) and coronary computed tomography angiography (CTA), have shed light on plaque characteristics and vulnerability to rupture leading to clinical events, the clinical implications of coronary physiological techniques associated with increased risk of clinical events remain underexplored. The incremental prognostic value of 3V-quantitative flow ratio (QFR) advocates for its integration into routine clinical evaluations as a non-invasive tool for risk stratification in coronary artery disease patients.