Organic Chimeras Based on Selenosugars, Steroids, and Fullerenes as Potential Inhibitors of the β-amyloid Peptide Aggregation.

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Tác giả: Andrea Carpentieri, Mauro De Nisco, Reinier Lemos, Silvana Pedatella, Yoana Pérez-Badell, Margarita Suárez

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Germany : ChemPlusChem , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 715076

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The aggregation of β-amyloid peptide (Aβ) is associated with neurodegenerative diseases such as Alzheimer's disease (AD). Several therapies aimed at reducing the aggregation of this peptide have emerged as potential strategies for the treatment of AD. This paper describes the design and preparation of new hybrid molecules based on steroids, selenosugars, and [60]fullerene as potential inhibitors of Aβ oligomerization. These moieties were selected based on their antioxidant properties and possible areas of interaction with the Aβ. Cyclopropanations between C

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