Conditional heterozygous loss of kit receptor tyrosine kinase in neural crest cell lineage is associated with midline cleft lip and bifid nose deformity.

• Tác giả: Hitomi Aoki, Akira Hara, Takahiro Kunisada, Hiroyuki Tomita
• Ngôn ngữ: eng
• Ký hiệu phân loại: 597.959 *Anguinomorphoidea
• Thông tin xuất bản: Netherlands : Journal of oral biosciences , 2025
• Bộ sưu tập: NCBI
• ID: 715594

Tóm tắt

 OBJECTIVES: The receptor tyrosine kinase Kit is expressed in cells derived from the trunk neural crest (NC), such as melanocytes
  however, its role in cranial NC cell development is not fully understood. METHODS: We investigated the effects of the heterozygous loss of Kit in NC cells during embryonic development by mating Kit RESULTS: Compared with control littermates, Wnt1-Cre
  Kit CONCLUSION: Conditional heterozygous loss of Kit in Wnt1-Cre
  Kit