Halogen-based redox-active materials represent an important class of materials in aqueous electrochemistry. The existence of versatile halogen species and their rich bonding coordination create great flexibility in designing new redox couples. Novel redox reaction mechanisms and electrochemical reversibility can be unlocked in specifically configurated electrolyte environments and electrodes. In this review, the halogen-based redox couples and their appealing redox chemistries in aqueous batteries, including redox flow batteries and traditional static batteries that have been studied in recent years, are discussed. New aqueous electrochemistry provides hope to outperform the state-of-the-art materials and systems that are facing resources and performance limitation, and to enrich the existing battery chemistries.