Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023.

• Tác giả: Eliza Alexander, James Brown, Cathleen Chan, Martin Dedicoat, Elena Ferran, Ana Gibertoni-Cruz, Marc Lipman, Esther Robinson, Noorann Sheikh
• Ngôn ngữ: eng
• Ký hiệu phân loại: 722.33 *Ancient Palestinian architecture
• Thông tin xuất bản: United States : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2025
• Bộ sưu tập: NCBI
• ID: 715617

Tóm tắt

Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found it present in 1.4% overall and 23.9% of multidrug-resistant TB. Routine sequencing allows clinically-relevant resistance surveillance and should be widely adopted.