Neutralizing Antibody Responses to Chlamydia trachomatis in Women and Associations With Chlamydia Outcomes.

• Tác giả: Robert C Brunham, Gary Cutter, Chuanbin Dai, William M Geisler, Kanupriya Gupta, Hong Yu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.9101 Other diseases
• Thông tin xuất bản: United States : The Journal of infectious diseases , 2025
• Bộ sưu tập: NCBI
• ID: 715629

Tóm tắt

 We assessed neutralizing antibody responses in a well-characterized cohort of 60 women with different Chlamydia trachomatis infection outcomes noted at a treatment visit and 3-month follow-up. We found varying rates of neutralization (inhibition of C trachomatis) in sera at different dilution levels and varying neutralizing antibody titers across outcomes. Median neutralization rates were significantly higher in sera at high dilutions (1:320-1:1280) from women with spontaneous resolution vs persisting infection before treatment (all P <
  .05). These findings suggest that neutralizing antibody responses may contribute to protective immunity against chlamydia.