Mouse Models for Pancreatic Ductal Adenocarcinoma are Affected by the cre-driver Used to Promote KRAS

• Tác giả: Filip Bednar, Timothy Frankel, Oneeb Hassan, Justine Lau, Mickenzie B Martin, Jake McGue, Fatemeh Mousavi, Christopher L Pin, Nur Renollet, Parisa Shooshtari, Joyce Thompson
• Ngôn ngữ: eng
• Ký hiệu phân loại: 658.32259 Personnel management (Human resource management)
• Thông tin xuất bản: United States : Cellular and molecular gastroenterology and hepatology , 2025
• Bộ sưu tập: NCBI
• ID: 715655

Tóm tắt

BACKGROUND & AIMS: The fundamental biology of pancreatic ductal adenocarcinoma has been greatly impacted by the characterization of genetically engineered mouse models that allow temporal and spatial activation of oncogenic KRAS (KRAS METHODS: We performed morphological and molecular analysis of 3 genetically engineered mouse models that express a tamoxifen-inducible cre-recombinase to activate Kras RESULTS: Up to 2 months after tamoxifen induction of KRAS CONCLUSIONS: These findings suggest Ptf1a haploinsufficiency in Ptf1a