Unexpected Formation of a Chiral spiro-system in the Reaction of the Dilithium Derivative of Hexafluorocumyl Alcohol with N-(t-butylsulfenyl)phthalimide.

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Tác giả: Józef Drabowicz, Lesław Sieroń, Adrian Zając, Remigiusz Żurawiński

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Germany : ChemPlusChem , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 715841

An unexpected course of the reaction of hexafluorocumyl alcohol dilithium derivative 2 with N-(t-butylsulfenyl)phthalimide (3) has been presented. The process proceeded under mild conditions and resulted in previously undescribed chiral spiro-system- 3',3'-bis(trifluoromethyl)-3H,3'H-1,1'-spirobis(isobenzofuran)-3-one (5) as the only product. A detailed spectral analysis of the product has been provided, and mechanistic aspects have been investigated. Attempts to separate the enantiomers of compound 5 using a semipreparative HPLC method with a chiral stationary phase column have been described. The repeatability of the reaction using analogs of alcohol 4 has also been tested. DFT calculations of absolute configuration assignment have been performed successfully.
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