Case-Control Study of Cervicovaginal β/γ-Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer.

• Tác giả: Adaora A Adimora, Kathryn Anastos, Jessica M Atrio, Natalie Bachman, Robert D Burk, Gypsyamber D'Souza, Isam-Eldin Eltoum, Margaret Fischl, Lisa Flowers, Nancy A Hessol, Marla J Keller, L Stewart Massad, Howard Minkoff, Igho Ofotokun, Joel M Palefsky, Lisa Rahangdale, Catalina Ramirez, Lorraine Sanchez-Keeland, Sadeep Shrestha, Howard D Strickler, Mykhaylo Usyk, Rodney Wright, Xianhong Xie, Xiaonan Xue
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: United States : The Journal of infectious diseases , 2025
• Bộ sưu tập: NCBI
• ID: 715884

Tóm tắt

 We studied cervicovaginal β/γ-human papillomavirus (HPV) and their relationship to cervical precancer in women with human immunodeficiency virus
  having previously reported strong positive associations of β/γ-HPV with incident head and neck cancer in the general population. Case patients (n = 124) had cervical intraepithelial neoplasia (CIN) 3 or 2. Controls (n = 247) were individually matched 2:1 to case patients. Unexpectedly, multivariate analyses found strong inverse associations between β/γ-HPV and CIN-2/3 (odds ratio, 0.19 [95% confidence interval, .04-.86]
  P = .03
  Ptrend <
  .01]). This is, to our knowledge, the first study of β/γ-HPV and cervical precancer. If confirmed, a strong inverse (protective) association would be of potential clinical and biologic relevance.