Role of trigeminal ganglion satellite glial cells in masseter muscle pain hypersensitivity.

• Tác giả: Yoshinori Hayashi, Suzuro Hitomi, Koichi Iwata, Sho Sawada, Masamichi Shinoda, Hirotaka Shinozuka, Yoshiyuki Yonehara
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Journal of oral biosciences , 2025
• Bộ sưu tập: NCBI
• ID: 715906

Tóm tắt

OBJECTIVES: The underlying mechanism of masseter muscle pain hypersensitivity by sustained masseter muscle contraction (SMMC) is not well understood. This study aimed to examine whether the activation of satellite glial cells in the trigeminal ganglion (TG) contributes to masseter muscle pain hypersensitivity induced by SMMC. METHODS: Electrodes were placed on the masseter muscle fascia of rats to induce strong contractions, by daily electrical stimulation. Pain sensitivity in the masseter muscle was measured and the activation level of satellite glial cells in the TG was examined. The localization of P2Y RESULTS: SMMC induced masseter muscle pain hypersensitivity and activation of satellite glial cells. P2Y CONCLUSION: SMMC-induced activation of satellite glial cells though the P2Y