Clinicopathological significance of androgen receptor expression and tumor infiltrating lymphocytes in triple-negative breast cancer: a retrospective cohort study.

• Tác giả: Nami Hirakawa, Yuka Kajiura, Naoki Kanomata, Takeshi Ushigusa, Hideko Yamauchi, Atsushi Yoshida
• Ngôn ngữ: eng
• Ký hiệu phân loại: 333.822 Coal
• Thông tin xuất bản: Japan : Breast cancer (Tokyo, Japan) , 2025
• Bộ sưu tập: NCBI
• ID: 716116
• Chủ đề: 1. Clinicopathological; 2. Significance; 3. Of

Tóm tắt

BACKGROUND: Triple-negative breast cancer (TNBC) is a serious disease with limited treatment options. We explored the significance of androgen receptor (AR) expression and tumor-infiltrating lymphocytes (TILs) in predicting neoadjuvant chemotherapy (NAC) resistance in TNBC, hypothesizing that AR/TIL classification using pretreatment biopsies can identify NAC-resistant subgroups and improve the understanding of apocrine differentiation. METHODS: This retrospective study included 156 consecutive patients with TNBC treated with NAC. AR immunostaining was defined positive if ≥ 1% of the tumor cell nuclei were stained. Stromal TIL levels were assessed, with high levels defined as ≥ 50%. Apocrine differentiation was detected using an anti-15-PGDH antibody. The pathological response to NAC was evaluated. RESULTS: Overall, 36% (n = 56) of the patients achieved a pathological complete response (pCR). AR CONCLUSIONS: AR/TIL classification using pretreatment biopsies identified TNBC subgroups with distinct NAC responses and prognoses. AR