Synthesis of New Enantiopure Aminoalcohol Fluorenes as Promising Antimalarial Compounds.

• Tác giả: Patrice Agnamey, Céline Damiani, Alexandra Dassonville-Klimpt, Jean Guillon, Aurélie Herrero, Mathieu Marchivie, René Momha, Romain Mustière, Jérémy Schneider, Pascal Sonnet, Camille Tisnerat, Anne Totet
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : ChemMedChem , 2025
• Bộ sưu tập: NCBI
• ID: 716201

Tóm tắt

Herein, we report the design, synthesis, and characterisation of a new library of enantiopure aminoalcohol fluorenes, as well as their in vitro evaluation for biological properties, including activity against two strains of P. falciparum (3D7 and W2) and cytotoxicity on the HepG2 cell line. All tested compounds exhibited good to excellent antimalarial potency with IC