Double-Dynamic-Bond Cross-Linked Hydrogel Adhesive with Cohesion-Adhesion Enhancement for Emergency Tissue Closure and Infected Wound Healing.

• Tác giả: Rui Dai, Shi-Yu Hu, Zhong-Ming Li, Xu Peng, Hao-Jie Tan, Haibo Wang, Zhi-Guo Wang, Jia-Zhuang Xu, Ming Yan
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Advanced healthcare materials , 2025
• Bộ sưu tập: NCBI
• ID: 716512

Tóm tắt

The hydrogel adhesives with strong tissue adhesion and biological characteristics are urgently needed for injury sealing and tissue repair. However, the negative correlation between tissue adhesion and the mechanical strength poses a challenge for their practical application. Herein, a bio-inspired cohesive enhancement strategy is developed to prepare the hydrogel adhesive with simultaneously enhanced mechanical strength and tissue adhesion. The double cross-linked network is achieved through the cooperation between polyacrylic acid grafted with N-hydroxy succinimide crosslinked by tannic acid and cohesion-enhanced ion crosslinking of sodium alginate and Ca