Discovery and Optimization of a Series of Novel Morpholine-Containing USP1 Inhibitors.

• Tác giả: Xubin Bao, Jinxue He, Xiajuan Huan, Hongrui Li, Benjin Liu, Tongchao Liu, Ze-Hong Miao, Ruyue Ren, Shanshan Song, Ruifeng Wang, Bing Xiong, Jiahao Xu, Ting Yu, Junjie Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 364.04 Special topics of criminology
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 716676

Tóm tắt

Ubiquitin-specific protease 1 (USP1), a well-known member of the deubiquitinating enzymes, serves as a key regulator in DNA damage repair (DDR) processes. Herein, we utilized ring-opening and cyclization strategies based on KSQ-4279 to design a novel series of USP1 inhibitors featuring a morpholine scaffold. Notably, compound