Herbal Formula Yi-Fei-Jie-Du-Tang Regulates Epithelial-Mesenchymal Transition and Vasculogenic Mimicry in Lung Cancer via HIF1A-Mediated Ferroptosis.

• Tác giả: Qingying Wang, Shanshan Wang, Yang Wu, Yongjian Wu, Die Yang, Chengjia Yuan, Xiaochun Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 922.945 *Hindus
• Thông tin xuất bản: Germany : Advanced biology , 2025
• Bộ sưu tập: NCBI
• ID: 716808

Tóm tắt

Traditional Chinese medicine (TCM) Yi-Fei-Jie-Du-Tang (YFJDT) has shown potential in lung cancer treatment. However, the mechanisms underlying the effects of YFJDT on lung cancer remain unclear. Bioinformatics analysis is conducted to identify potential targets of YFJDT. The impact of YFJDT on hypoxia-inducible factor 1 alpha (HIF1A), ferroptosis, and vasculogenic mimicry (VM) is investigated using xenograft tumor models and A549 cells. Additionally, A549 cells are stimulated with CoCl