D-allulose enhances lipid oxidation in HepG2 cells via peroxisome proliferator-activated receptor α (PPARα).

• Tác giả: Jennifer Batch, Lauren Graham, Michael J Haas, Arshag D Mooradian, Firas Warda
• Ngôn ngữ: eng
• Ký hiệu phân loại: 230.071 Education in Christianity, in Christian theology
• Thông tin xuất bản: Netherlands : Biochimica et biophysica acta. Molecular and cell biology of lipids , 2025
• Bộ sưu tập: NCBI
• ID: 716843

Tóm tắt

Lipid accumulation in hepatocytes in non-alcoholic steatohepatitis (NASH) is attributed partly to loss of insulin-responsiveness and/or an increased pro-inflammatory state. Since the rare sugar D-allulose has insulin mimetic and anti-inflammatory properties, its effects on lipid accumulation in liver-derived cells was tested. In HepG2 cells exposed to 200 μM oleic acid for 72 h, D-allulose treatment decreased intracellular lipid accumulation with an IC