Chronic kidney disease - Epidemiology collaboration equations even using cystatin C overestimate renal function in patients with chronic intestinal failure on long-term parenteral nutrition.

• Tác giả: Charlotte Bergoin, Cécile Chambrier, Laurence Derain-Dubourg, Georges Kosmadakis, Madeleine Lauverjat, Sandrine Lemoine
• Ngôn ngữ: eng
• Ký hiệu phân loại: 297.1248 Sources of Islam
• Thông tin xuất bản: England : Clinical nutrition ESPEN , 2025
• Bộ sưu tập: NCBI
• ID: 716869

Tóm tắt

 BACKGROUND & AIMS: Accurate determination of renal function is of utmost importance in chronic intestinal failure (CIF) patients on parenteral nutrition (PN) and creatinine based glomerular filtration rate (GFR) estimating equation is used in clinical practice. The aim of the present study is to evaluate the reliability of 3 CKD-EPI GFR estimating equations (eGFR) (creatinine, cystatin C or combined creatinine/cystatin C) compared with the reference method which is Iohexol plasma clearance (mGFR) in patients on long-term PN (>
 6 months) owing to CIF. METHODS: Forty-eight patients (25 F) with a median age of 58 years (Interquartile Range:15) presenting CIF on PN for a median duration of 93 months (75) were included in this retrospective study. Concordance studies were performed by Pearson correlation and Bland-Altman method (Mean bias-Confidence Interval). Accuracy of the formulas was estimated with P30 representing the proportion of eGFR within 30 % of mGFR (±30 %). RESULTS: Median mGFR was 65 (29) ml/min/1.73 m CONCLUSIONS: The eGFR estimating CKD-EPI equations significantly miscalculate the true levels of renal function in patients with CIF on PN and should be used with caution in daily clinical practice.