A rubrerythrin locus of Clostridioides difficile encodes enzymes that efficiently detoxify reactive oxygen species.

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Tác giả: Silvia Dittmann, Simon Keweloh, Robert Knop, Johanna Pukall, Susanne Sievers, Daniela Zühlke

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Anaerobe , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 716941

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OBJECTIVES: The microaerophilic conditions in the large intestine and reactive oxygen species (ROS) produced by the immune system represent a challenge for the strictly anaerobic pathogen Clostridioides difficile, which protects itself by a variety of oxidative stress proteins. Four of these are encoded in an operon that has been implicated in the detoxification of H METHODS: Recombinant proteins were overexpressed in C. difficile and purified anaerobically by affinity chromatography. The H RESULTS: Proposed roles of the investigated proteins in the detoxification pathways of ROS could partially be demonstrated. Specifically, Rbr and glutamate dehydrogenase synergistically detoxify H CONCLUSIONS: The investigated gene locus codes for an oxidative stress operon whose members have the potential to neutralize O

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