Alginate dressings are widely used in wound treatment for their healing and hemostatic properties and their capacity to drain exudate. However, a clear understanding of the heterogeneity within this class of dressings is lacking. Numerous sources of variability exist between alginate dressings: their composition (% of calcium alginate relative to other components), the ratio of D-Mannuronic and L-Guluronic acids in the alginate fraction, their purity (presence of toxic contaminants), and the shape of their fibers (surface and thickness). These parameters affect the performance and safety of alginate dressings, which may thus not be interchangeable in clinical practice. Therefore, clinicians must be aware of these differences to ensure optimal treatment and avoid complications or suboptimal healing. The objective of this study was to compare six alginate dressings to conclude or not on their equivalence. The results obtained demonstrate considerable variability between alginate dressings in the assessed characteristics: composition, Ca