Influenza H5Nx viruses are susceptible to MEK1/2 inhibition by zapnometinib.

• Tác giả: Benjamin Ambrosy, Martin Beer, Linda Brunotte, Duygu Merve Caliskan, Sriram Kumar, Stephan Ludwig, Nicole Oberberg, Franziska Rodner, André Schreiber
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Emerging microbes & infections , 2025
• Bộ sưu tập: NCBI
• ID: 717222

Tóm tắt

Highly pathogenic avian influenza A viruses (HPAIV) pose a significant threat to both animal and human health. These viruses have the potential to cause severe respiratory and systemic infections in birds and several mammalian species. The recent global outbreak of the H5N1 clade 2.3.4.4b spread in wild and domestic birds is now considered to be a panzoonosis. Spillover events in dairy cattle farms in the U.S. have highlighted the urgent need for effective antiviral therapies, especially in view of human infections. This study investigates the selective MEK1/2 inhibitor zapnometinib (ZMN) as a potential antiviral agent against HPAIVs. Our