Deficits in taste-guided behaviors and central processing of taste in the transgenic TDP-43

• Tác giả: Jennifer M Blackwell, Alfredo Fontanini, Camelia Yuejiao Zheng
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Neurobiology of disease , 2025
• Bộ sưu tập: NCBI
• ID: 717304

Tóm tắt

Frontotemporal dementia (FTD) is the second most prevalent form of presenile dementia. Patients with FTD show prominent chemosensory symptoms such as abnormal detection and recognition thresholds for various gustatory stimuli. The chemosensory symptoms of FTD may be related to damage of the gustatory insular cortex (GC) as the insular cortex is one of the primary targets in FTD disease progression. Little is known about how circuitry changes in GC lead to deficits in taste processing in FTD. Here we tested the hypothesis that gustatory deficits are present in a mouse model of FTD, and that they are related to abnormal patterns of neural activity in GC. We behaviorally evaluated a transgenic FTD mouse model overexpressing human TDP-43 with a Q331K mutation (TDP-43