Nurse turnover is a continuous problem in the Philippines, a social phenomenon evident in due to change in career and nurse migration. The purpose of this study was to comprehensively assess the willingness of Filipino nurses to pursue nursing careers using an extended and modified macroergonomic factor framework. This study collected 314 valid responses from nurses in the Philippines. An in-depth investigation was performed by analyzing factors under self-efficacy, function, opportunity, organizational behavior, coping style, occupational commitment, career satisfaction, and life satisfaction influencing the career pursuance of Filipino nurses beyond the scope of their initial entry into the profession. Using higher-order structural equation modeling analysis, results showed the direct influence of self-efficacy, function, opportunity, organizational behavior, coping style, reflective style, suppressive style, reactive style, while occupational commitment and career satisfaction directly influenced the pursuance of nursing career. The results of this study have provided actionable insights and strategies, thus mitigating the issues the Philippines faces regarding the reduced pursuance of a nursing career. The study highlighted the urgent need to deal with systematic challenges and establish favorable regulations to provide an intricate environment formed by a variety of institutional, social, and economic factors. Lastly, the framework used in this study could be implemented and extended in other service industries to assess pursuit willingness, enhancing the retention of local and domestic nurses in the country.