Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion.

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Tác giả: Katlynn J Emaus, Garrett M Fogo, Maik Hüttemann, Sarita Raghunayakula, Thomas H Sanderson, Gary Shangguan, Francisco J Torres Torres, Joseph M Wider

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Autophagy , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 717466

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Mitochondrial damage and dysfunction are hallmarks of neuronal injury during cerebral ischemia-reperfusion (I/R). Critical mitochondrial functions including energy production and cell signaling are perturbed during I/R, often exacerbating damage and contributing to secondary injury. The integrity of the mitochondrial proteome is essential for efficient function. Mitochondrial proteostasis is mediated by the cooperative forces of mitophagy and intramitochondrial proteolysis. The aim of this study was to elucidate the patterns of mitochondrial protein dynamics and their key regulators during an

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