Despite the significant advancements in multiple myeloma therapy over the last decade, current unmet needs include populations of patients who continue to have inferior outcomes, such as those with high-risk cytogenetics, elderly and frail patients, plasma cell leukemia, central nervous system involvement, and extramedullary disease. Though T-cell redirecting therapies have shown excellent efficacy in advanced multiple myeloma, the ability of these therapies to overcome high-risk disease such as extramedullary involvement in myeloma is an area of critical attention. In this review, we seek to examine the specific impact of currently available data of T-cell redirecting therapies, including approved and investigational chimeric antigen receptor T-cell and bispecific antibody therapies, on outcomes in patients with extramedullary myeloma.