Diabetes-related sores and ulcers are quite common around the world and can cause complicated disruptions to both patient compliance and socioeconomic structure. Diabetic wounds take longer to heal due to pathophysiological causes, persistent infections, and increasingly severe medical problems. Nanoparticles (NPs) derived from nanotechnology have drawn interest due to their revolutionary potential in understanding the biological milieu and offering therapeutic strategies for wound healing. In this regard, the potential of yttrium oxide nanoparticles (YNPs) has been studied extensively to understand their efficacy in diabetic wound healing. Yttrium oxide nanoparticles having size in the range of 2-10 nm were prepared and incorporated into nanofibrous mats consisting of polyurethane as the matrix polymer, and leaf extract of