Our study breaks new ground by examining the adverse effects of family ostracism on employees' negligence behavior and knowledge hoarding, a fact that has been overlooked in the literature. Drawing from the Stress-Non-Equilibrium-Compensation Approach, we investigate the development of a consolidative framework that explores the mediating role of emotional exhaustion and workplace envy in the relationship between family ostracism on employee negligence behavior and knowledge hoarding along with the moderating role of coping strategies. We utilized the multisource and time lag approach to collect data from 307 university teachers, and it was analyzed through structural equation modeling (SEM). Our study results reveal that family ostracism is negatively related to employee negligence behavior and knowledge hoarding. Furthermore, coping strategies moderated the sequentially mediated relationships between family ostracism and employees' negligence behavior and knowledge hoarding, such that the relationships are weaker for employees with high vs. low coping strategies. Finally, our study stresses that female employees are vulnerable to family ostracism, often leading to negligence behavior and knowledge hoarding. The theoretical and practical implications of this study are discussed.